2'-O-Me Nucleosides
2'-O-Methyl-5-methyl uridine
Quick view. We supply 2'-O-Methyl-5-methyl uridine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 55486-09-4. Catalog target purity: Specification on request.
Product profile
2'-O-Methyl-5-methyl uridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H16N2O6; molecular weight 272.25).
2'-O-Methyl-5-methyl uridine — 5-Methyl-2’-O-methyluridine is one of three oligonucleotide in platinum-derivatized homopyrimidine triplex-forming oligonucleotides (Pt-TFOs) useful in crosslinking to the transcribed strand in the human androgen receptor (AR) gene. Inhibitory activity against M. bovis and M. avium.
For 2'-O-Methyl-5-methyl uridine, reported solubility: DMSO (Slightly), Methanol (Slightly, Sonicated). Storage: under inert gas (nitrogen or Argon) at 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-METHYLRIBOTHYMIDINE
- 5,2'-O-Dimethyluridine
- 5-METHYL-2'-O-METHYLURIDINE
- 55486-09-4 2'-O-Methyl-5-methyluridine 4518
- 5-methyl-5-METHYLURIDINE
Useful catalog search terms
- CAS 55486-09-4
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C11H16N2O6/c1-5-3-13(11(17)12-9(5)16)10-8(18-2)7(15)6(4-14)19-10/h,6-8,10,14-15H,4H2,1-2H3,(H,12,16,17)/t6-,7-,8-,10-/m1/s |
| InChIKey | YHRRPHCORALGKQ-FDDDBJFASA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OC)[C@@H]1O |
| Melting point | 183-186°C |
| Density | 1.47±0.1 g/cm3(Predicted) |
| pKa | 9.55±0.10(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Methyl-5-methyl uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5-methyl uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-Me-2-NH₂-rA
2'-O-Me Nucleosides · CAS: 80791-87-3
BX-2OMN-00032'-O-Me-7-deaza-rA
2'-O-Me Nucleosides · CAS: 68345-70-0
BX-2OMN-00042'-O-Me-N6-Me-rA
2'-O-Me Nucleosides · CAS: 57817-83-1
BX-2OMN-00052'-O-Me-rI
2'-O-Me Nucleosides · CAS: 3881-21-8
BX-MN-01752'-O-Me-rC
2'-O-Me Nucleosides · CAS: 2140-72-9
BX-MN-01782'-O-Me-rG
2'-O-Me Nucleosides · CAS: 2140-71-8
Frequently asked questions
Can the package size for 2'-O-Methyl-5-methyl uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0096 and CAS 55486-09-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.