2'-O-Me Nucleosides
2'-O-Methyl-5'-O-DMTr-5-iodouridine
Quick view. We supply 2'-O-Methyl-5'-O-DMTr-5-iodouridine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 588691-24-1. Catalog target purity: Specification on request.
Product profile
2'-O-Methyl-5'-O-DMTr-5-iodouridine is classified as nucleoside or protected nucleoside intermediate (Formula C31H31IN2O8; molecular weight 686.49).
2'-O-Methyl-5'-O-DMTr-5-iodouridine — 5’-O-(Dimethoxytrityl)-5-iodo-2’-O-methyluridine is a reagent used in the synthesis of oligonucleotides (ODNs) containing 5-(N-aminohexyl)carbamoyl-2’-O-methyluridine which is resistant to nucleolytic hydrolysis.
For 2'-O-Methyl-5'-O-DMTr-5-iodouridine, storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-5-iodo-2'-O-methyluridine
- 5-I-DMT-2'-O-Me-Ur
- 2'-O-Methyl-5'-O-DMT-5-iodouridine
- 5'-O-(DMT)-5-IODO-2'-O-METHYLURIDINE
- 5'-O-(DIMETHOXYTRITYL)-5-IODO-2'-O-METHYLURIDINE
- 2’-O-Methyl-5’-O-(4,4’-dimethoxytrityl)-5-iodouridine
- 5'-O-(4,4'-Dimethoxytrityl)-5-Iodo-2'-O-Methyluridine
- Uridine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-5-iodo-2'-O-Methyl-
Useful catalog search terms
- CAS 588691-24-1
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C31H31IN2O8/c1-38-22-13-9-20(10-14-22)31(19-7-5-4-6-8-19,21-11-15-23(39-2)16-12-21)41-18-25-26(35)27(40-3)29(42-25)34-17-24(32)28(36)33-30(34)37/h4-17,25-27,29,35H,18H2,1-3H3,(H,33,36,37)/t25-,26-,27-,29-/m1/s |
| InChIKey | VYNNFLLSYDWMCJ-LTGLEFCMSA-N |
| SMILES | CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)I)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Methyl-5'-O-DMTr-5-iodouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Methyl-5'-O-DMTr-5-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Methyl-5'-O-DMTr-5-iodouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0097 and CAS 588691-24-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.