DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dG(iBu)
Quick view. We supply 5'-O-DMTr-2'-F-dG(iBu) as a DMTr-protected 2'-fluoro nucleoside intermediate for preparing 2'-F phosphoramidites, succinates or other oligonucleotide building blocks. CAS 144089-96-3. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-F-dG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C35H36FN5O7; molecular weight 657.69).
5'-O-DMTr-2'-F-dG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-F-dG(iBu), storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dGiBu
- 5'-DMT-2'-F-ibu-dG
- 5'-O-DMT-N2-ibu-2'-F-dG
- 5'-DMT-2'-F-ibu-dG 144089-96-3
- 5'-O-DMT-2'-F-Isobutyryl-Deoxyguanosine
- 5-O-DMT-N2-ISOBUTYRYL-2-FLUORO-2-DEOXYGUANOSINE
- 5'-O-DMT-2'-Fluoro-N2-isobutyryl-2'-deoxyguanosine
- N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-fluoro-guanosine
Useful catalog search terms
- CAS 144089-96-3
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-fluoro modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
| SMILES | C(NC1=NC(=O)C2=C(N1)N([C@H]1[C@H](F)[C@H](O)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C(C)C |&1:10,11,13,15,r| |
| InChIKey | QQQXVSXVBFQISZ-SEXLECIHNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-F-dG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0063 and CAS 144089-96-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.