DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dU
Quick view. We supply 5'-O-DMTr-2'-F-dU as a DMTr-protected 2'-fluoro nucleoside intermediate for preparing 2'-F phosphoramidites, succinates or other oligonucleotide building blocks. CAS 146954-74-7. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-F-dU is classified as nucleoside or protected nucleoside intermediate (Formula C30H29FN2O7; molecular weight 548.56).
5'-O-DMTr-2'-F-dU — 2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.
For 5'-O-DMTr-2'-F-dU, storage: 2-8°C. Form: Powder.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-U
- DMT-2'-F-dU
- 5'-DMT-2'-F-dU
- 5'-O-DMT-2'-F-dU
- 1-((2R,3R,4R,5R)
- -5-((Bis(4-methoxyphenyl)
- 2'-Deoxy-5'-O-DMT-2'-fluorouridine
- 5'-O-DMT-2'-Fluoro-2'-deoxyuridine
Useful catalog search terms
- CAS 146954-74-7
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-fluoro modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Powder |
| Color | White to Pale Yellow |
| SMILES | N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2=CC=C(C=C2)OC)C2=CC=C(C=C2)OC)[C@@H](O)[C@H]1F |&1:8,10,36,38,r| |
| InChIKey | CSSFZSSZXOCCJB-MNBKXICWNA-N |
| InChI | InChI=1S/C30H29FN2O7/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-27(35)26(31)28(40-24)33-17-16-25(34)32-29(33)36/h3-17,24,26-28,35H,18H2,1-2H3,(H,32,34,36)/t24-,26-,27-,28-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-F-dU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-F-dU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0061 and CAS 146954-74-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.