DMTr-protected Nucleosides
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu)
Quick view. We supply 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) as an isobutyryl-protected LNA guanosine intermediate for locked nucleic acid monomer preparation. CAS 206055-72-3. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C36H37N5O8; molecular weight 667.72).
5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu), high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-O,4'-C-methyleneguanosine
- 5'-O-DMT-2'-O-4'-C-Locked-rG(iBu)
Useful catalog search terms
- CAS 206055-72-3
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- conformationally locked sugar
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0036 and CAS 206055-72-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5'-O-DMTr-2'-O-4'-C-Locked-rG(iBu) or the named structural feature represented by this product.