DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rA
Quick view. We supply 5'-O-DMTr-2'-O-Me-rA as a DMTr-protected 2'-O-methyl nucleoside used as a precursor to 2'-OMe amidites, supports and modified RNA building blocks. CAS 103285-23-0. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-O-Me-rA is classified as nucleoside or protected nucleoside intermediate (Formula C32H33N5O6; molecular weight 583.65).
5'-O-DMTr-2'-O-Me-rA — 5’-ODMT-2’-OMe Adenosine is a derivative of Adenosine which is a nucleotide.
For 5'-O-DMTr-2'-O-Me-rA, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5’-ODMT-2’-OMe Adenosine
- 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-Adenosine
- Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl- (9CI)
- 5'-O-DMT-2'-O-Me-rA
Useful catalog search terms
- CAS 103285-23-0
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| Boiling point | 796.5±70.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| pKa | 13.09±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-Me-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0077 and CAS 103285-23-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.