DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rC(Ac)
Quick view. We supply 5'-O-DMTr-2'-O-Me-rC(Ac) as a DMTr-protected 2'-O-methyl nucleoside used as a precursor to 2'-OMe amidites, supports and modified RNA building blocks. CAS 199593-08-3. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-O-Me-rC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C33H35N3O8; molecular weight 601.65).
5'-O-DMTr-2'-O-Me-rC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-Me-rC(Ac), storage: 2-8°C. Form: Powder.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-OMe-Ac-C
- DMT-2'-OMe-Ac-dC
- 5'-DMT-2'-OMe-Ac-C
- N4-Ac-DMT-2'-OMe-Cr
- N4-Ac-DMT-2'-O-Me-5-Me-Cr
- 5'-O-DMT-2'-OMe-Acetyl-Cytidine
- N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE
- N4-Acetyl-5'-O-DMT-2'-O-methylcytidine
Useful catalog search terms
- CAS 199593-08-3
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| pKa | 10.19±0.20(Predicted) |
| Form | Powder |
| Color | White to Pale Yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1O |&1:25,27,39,42,r| |
| InChIKey | FINUHOJILDNELQ-URCGJLOONA-N |
| InChI | InChI=1S/C33H35N3O8/c1-21(37)34-28-18-19-36(32(39)35-28)31-30(42-4)29(38)27(44-31)20-43-33(22-8-6-5-7-9-22,23-10-14-25(40-2)15-11-23)24-12-16-26(41-3)17-13-24/h5-19,27,29-31,38H,20H2,1-4H3,(H,34,35,37,39)/t27-,29-,30-,31-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMT-OMe-rC(Ac) (N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine) is a nucleotide derivative that can be used to synthesize oligoribonucleotides.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rG(iBu)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00193'-O-DMTr-2'-O-Me-rU
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00203'-O-DMTr-dA(Bz)
DMTr-protected Nucleosides · CAS: 140712-79-4
BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00275'-O-DMTr-2'-O-(2-aminoethyl) -5-Me-rU
DMTr-protected Nucleosides · CAS: 242147-79-1
BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
DMTr-protected Nucleosides · CAS: 863408-41-7
Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0066 and CAS 199593-08-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.