DMTr-protected Nucleosides
5'-O-DMTr-2'-O-TBDMS-rG(iBu)
Quick view. We supply 5'-O-DMTr-2'-O-TBDMS-rG(iBu) as a protected guanosine intermediate for standard RNA phosphoramidite preparation. CAS 81279-39-2. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-TBDMS-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C41H51N5O8Si; molecular weight 769.96).
5'-O-DMTr-2'-O-TBDMS-rG(iBu) — 5''-O-DMT-2''-O-iBu-N-Bz-Guanosine (cas# 81279-39-2) is a nucleotide used in the preparation of 4''-C-methoxy-2''-deoxy-2''-fluoro modified ribonucleotides to improve metabolic stability and elicit efficient RNAi-mediated gene silencing.
For 5'-O-DMTr-2'-O-TBDMS-rG(iBu), storage: 2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 5'-DMT-2'-TBDMS-iBu-rG
- 5'-O-DMT-2'-O-TBDMS-ibu-rG
- 5'-O-DMT-2'-O-TBDMS-N2-ibu-rG
- 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
- 5'-O-DMT-2'-OTBDMS-N-isobutyryl-Guanosine
- 5'-O-DMT-N-isobutyryl-2'-O-TBDMS-guanosine
- 5'-O-DMT-2'-O-(tertbutyldimethylsilyl)-N-isobutyryl-Guanosine
- 2'-O-(tert-Butyldimethylsilyl)-5'-O-DMT-N-isobutyryl-guanosine
Useful catalog search terms
- CAS 81279-39-2
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- TBDMS protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection |
|---|---|
| Density | 1.25 |
| pKa | 9.16±0.20(Predicted) |
| Form | Solid |
| Color | White to light yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O |&1:25,27,44,53,r| |
| InChIKey | JMCNKJFOIJGYRG-HVXBIEPNNA-N |
| InChI | InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-34(54-55(8,9)40(3,4)5)33(47)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-TBDMS-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-TBDMS-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0045 and CAS 81279-39-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.