LNA Phosphoramidites
DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite as a benzoyl-protected 5-methyl LNA-C monomer for modified oligonucleotide synthesis. CAS 206055-82-5. Catalog target purity: ≥97%.
Product profile
DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C48H54N5O9P; molecular weight 875.96).
DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite, reported solubility: acetonitrile: 0.2M, clear, colorless. Storage: -20°C.
Names and search terms
Confirmed or normalized name variants
- LNA-5MeC(Bz)-3-CED-phosphoramidite
- DMT-locMeC(bz) Phosphoramidite configured for ABI
- 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Ac) Phosphoramidite
- N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methylene-5-methylcytidine
- DMT-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
- DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-2-cyanoethyl phosphoramidite
- LNA-5-Me-C(Bz)-Phosphoramidite
- BX-LP-0018
Useful catalog search terms
- CAS 206055-82-5
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- LNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Form | powder |
| Color | white to off-white |
| SMILES | C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@@]12CO[C@@H]([C@H](N3C=C(C)C(NC(C4C=CC=CC=4)=O)=NC3=O)O1)C2([H])OP(OCCC#N)N(C(C)C)C(C)C |&1:25,28,29,r| |
| InChIKey | XHILZPWJJJDDDY-QWQSVUEJNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-O-4'-C-Locked- rC(Ac)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0002DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0004DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-79-0
BX-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0006DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 709641-79-2
BX-LP-0007DMTr-2'-O-4'-C-Locked-rG(iBu)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-77-8
Frequently asked questions
Can the package size for DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LP-0003 and CAS 206055-82-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite or the named structural feature represented by this product.