LNA Phosphoramidites
DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite as a dmf-protected LNA guanosine monomer for modified oligonucleotide synthesis. CAS 709641-79-2. Catalog target purity: ≥95%.
Product profile
DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C44H53N8O8P; molecular weight 852.91).
DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite — LNA-Guanosine 3'-CE phosphoramidite (Lna-g amidite) is an essential building block to Locked Nucleic Acid (LNA) oligonucleotide synthesis, which includes a ribonucleoside linked by a methylene unit between the 2’-oxygen and 4’-carbon atoms, paralleling DNA polymer assembly.
For DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- LNA-guanosine 3'-CE phosphoramidite
- 2'-O-4'-C-Locked-rG(dmf) Phosphoramidite
- DMT-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
- DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-2-cyanoethyl phosphoramidite
- LNA-G(DMF)-Phosphoramidite
- BX-LP-0021
Useful catalog search terms
- CAS 709641-79-2
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- LNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Boiling point | 894.1±75.0 °C(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-LP-0003DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
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BX-LP-0004DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
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BX-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
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BX-LP-0007DMTr-2'-O-4'-C-Locked-rG(iBu)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LP-0006 and CAS 709641-79-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite or the named structural feature represented by this product.