Base-protected Nucleosides
2'-F-dC(Ac)
Quick view. We supply 2'-F-dC(Ac) as a protected 2'-fluoro nucleoside precursor for modified oligonucleotide and nucleotide synthesis. CAS 159414-97-8. Catalog target purity: Specification on request.
Product profile
2'-F-dC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C11H14FN3O5; molecular weight 287.24).
2'-F-dC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dC(Ac), form: Solid.
Names and search terms
Confirmed or normalized name variants
- Ac-2'-F-dC
- N4-Ac-2'-F-dC
- N4-Acetyl-2'-deoxy-2'-fluorocytidine
- N4-Acetyl-2'-Fluoro-2'-deoxycytidine
- Cytidine, N-acetyl-2'-deoxy-2'-fluoro-
- N4-Acetyl-2'-Fluoro-2'-deoxycytidine USP/EP/BP
Useful catalog search terms
- CAS 159414-97-8
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Density | 1.68±0.1 g/cm3(Predicted) |
| pKa | 10.13±0.20(Predicted) |
| Form | Solid |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](F)[C@@H]1O |
| InChI | InChI=1S/C11H14FN3O5/c1-5(17)13-7-2-3-15(11(19)14-7)10-8(12)9(18)6(4-16)20-10/h2-3,6,8-10,16,18H,4H2,1H3,(H,13,14,17,19)/t6-,8-,9-,10-/m1/s |
| InChIKey | NLXVKEFNBVLDLD-PEBGCTIMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-F-Ac-C (N-Acetyl-2′-deoxy-2′-fluorocytidine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0097 and CAS 159414-97-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.