LNA Locked Nucleosides
2'-O-4'-C-Locked-5-Me-rU
Quick view. We supply 2'-O-4'-C-Locked-5-Me-rU as a locked 5-methyl uridine/thymidine-like nucleoside for LNA oligonucleotide building blocks. CAS 206055-67-6. Catalog target purity: ≥98%.
Product profile
2'-O-4'-C-Locked-5-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C11H14N2O6; molecular weight 270.24).
2'-O-4'-C-Locked-5-Me-rU — 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
For 2'-O-4'-C-Locked-5-Me-rU, storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- 5-Methyl-2'-O,4'-C-methyleneuridine
- 5-Methyl-2’-O,4’-C-methyleneuridine, LNA-5MeU
- 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine
- 1-(2'-O,4-C-Methylene-beta-D-ribofuranosyl)thymine
- LNA-002 1-(2'-O, 4-C-Methylene-β-D- ribofuranosyl)thyMine
Useful catalog search terms
- CAS 206055-67-6
- Nucleoside or protected nucleoside intermediate
- conformationally locked sugar
- LNA Locked Nucleosides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar |
|---|---|
| Melting point | 196-198 °C |
| Density | 1.598 |
| pKa | 9.46±0.10(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-4'-C-Locked-5-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-5-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-5-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0003 and CAS 206055-67-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-4'-C-Locked-5-Me-rU or the named structural feature represented by this product.