2'-O-Me Nucleosides
2'-O-Me-7-deaza-rA
Quick view. We supply 2'-O-Me-7-deaza-rA as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 68345-70-0. Catalog target purity: ≥97%.
Product profile
2'-O-Me-7-deaza-rA is classified as nucleoside or protected nucleoside intermediate (Formula C12H16N4O4; molecular weight 280.28).
2'-O-Me-7-deaza-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-7-deaza-rA, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 2’-O-Methyl-7-deazaadenosine
- 7-(2-Omethyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-O-methyl-β-D-ribofuranosyl)-
Useful catalog search terms
- CAS 68345-70-0
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Boiling point | 602.1±55.0 °C(predicted) |
| Density | 1.70±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
| pKa | 12.69±0.70(predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-7-deaza-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-7-deaza-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0003 and CAS 68345-70-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.