Base-protected Nucleosides
2'-O-Me-rG(DMF)
Quick view. We supply 2'-O-Me-rG(DMF) as an N2-DMF protected 2'-O-methyl guanosine intermediate for RNA monomer and therapeutic oligonucleotide building-block synthesis. CAS 183737-04-4. Catalog target purity: ≥97%.
Product profile
2'-O-Me-rG(DMF) is classified as nucleoside or protected nucleoside intermediate (Formula C14H20N6O5; molecular weight 352.35).
2'-O-Me-rG(DMF) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-Me-rG(DMF), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-DMF-2'-OMe-G
- N2-DMF-2'-OMe-rG
- N2-dmf-2'-O-Me-Gr
- N2- Dimethylaminomethylene -2'-O-Methyl-Guanosine
- N-[(Dimethylamino)methylene]-2'-O-methylguanosine
- Guanosine, N-[(diMethylaMino)Methylene]-2'-O-Methyl-
Useful catalog search terms
- CAS 183737-04-4
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rG(DMF) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rG(DMF) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0010 and CAS 183737-04-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.