2'-O-MOE Nucleosides
2'-O-MOE-5-Me-rC
Quick view. We supply 2'-O-MOE-5-Me-rC as a methoxyethyl 5-methyl cytidine nucleoside used in antisense oligonucleotide chemistry. CAS 244105-55-3. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-5-Me-rC is classified as nucleoside or protected nucleoside intermediate (Formula C13H21N3O6; molecular weight 315.32).
2'-O-MOE-5-Me-rC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-MOE-5-Me-rC, reported solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly). Storage: Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5-Methyl-2'
- -methoxyethoxycytosine
- 5-Methyl-2'-methoxyethoxycytosine
- 5-Methyl-2'-methoxyethoxycytosine
- 2'-O-(2-Methoxyethyl)-5-Methyl- cytidine
- Cytidine, 2'-O-(2-Methoxyethyl)-5-Methyl-
- 5-Methyl-2'-methoxyethoxycytosine ISO 9001:2015 REACH
- 4-((2-Methoxyethoxy)aMino)-5-MethylpyriMidin-2(1H)-one
Useful catalog search terms
- CAS 244105-55-3
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Melting point | >70°C(dec) |
| Boiling point | 536.5±60.0 °C(Predicted) |
| Density | 1.52 |
| pKa | 13.36±0.70(Predicted) |
| Form | Solid |
| Color | Off-White to Light Yellow |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(N)=NC2=O)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C13H21N3O6/c1-7-5-16(13(19)15-11(7)14)12-10(21-4-3-20-2)9(18)8(6-17)22-12/h5,8-10,12,17-18H,3-4,6H2,1-2H3,(H2,14,15,19)/t8-,9-,10-,12-/m1/s |
| InChIKey | GUEIFVRYWPOXHJ-DNRKLUKYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-5-Me-rC or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-5-Me-rC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0167 and CAS 244105-55-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.