2'-O-Propargyl Nucleosides
2'-O-propargyl-rA
Quick view. We supply 2'-O-propargyl-rA as an alkyne-functional adenosine nucleoside for clickable RNA/oligo modification. CAS 151390-97-5. Catalog target purity: Specification on request.
Product profile
2'-O-propargyl-rA is classified as nucleoside or protected nucleoside intermediate (Formula C13H15N5O4; molecular weight 305.29).
2'-O-propargyl-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-propargyl-rA, copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
Names and search terms
Confirmed or normalized name variants
- 2'-O-propargyl-Ar
- 2'-O-Propargyladenosine
- 2'-O-propynyl-Adenosine
- 2'-O-2-propynyl-Adenosine
- 2'-O-(2-Propyn-1-yl)adenosine
- Adenosine, 2'-O-2-propyn-1-yl-
- 2’-O-Propargyladenosine,2’-O-(2-Propyn-1-yl)adenosine
Useful catalog search terms
- CAS 151390-97-5
- Nucleoside or protected nucleoside intermediate
- alkyne click handle
- 2'-O-Propargyl Nucleosides
Physicochemical data
| Key chemistry motifs | alkyne click handle |
|---|---|
| Boiling point | 655.1±65.0 °C(Predicted) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| pKa | 13.00±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
These points describe 2'-O-propargyl-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-propargyl-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0165 and CAS 151390-97-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-propargyl-rA or the named structural feature represented by this product.