Cyclic Dinucleotides
3',3'-cGAMP
Quick view. We supply 3',3'-cGAMP as a canonical 3'-5'-linked cyclic dinucleotide for comparative innate-immune signaling research. CAS 849214-04-6. Catalog target purity: ≥98%.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
3',3'-cGAMP is classified as cyclic dinucleotide second messenger or analog (Formula C20H24N10O13P2; molecular weight 674.41).
3',3'-cGAMP — c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.
For 3',3'-cGAMP, storage: -20°C. Form: powder.
Names and search terms
Confirmed or normalized name variants
- cGAMP
- 3',3'-cyclic GMP-AMP
- c-GpAp
- di-GAMP
- di-cGAMP
- Cyclic GMP-AMP
- cGAMP ammonium salt
- cGAMP (Cyclic GMP-AMP
Useful catalog search terms
- CAS 849214-04-6
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Linkage | Two 3'-5' phosphodiester linkages |
| Supply form | Dry research material |
| Boiling point | 1159.9±75.0 °C(Predicted) |
| Density | 2.61±0.1 g/cm3(Predicted) |
| pKa | 0.96±0.70(Predicted) |
| Form | powder |
| Color | white to beige |
| SMILES | c1nc(N)c2nc[n]([C@H]3[C@@H](O)[C@@H]4OP(O)(=O)OC[C@@H]5O[C@@H]([n]6cnc7C(=O)N=C(N)Nc67)[C@@H](O)[C@@H]5OP(O)(=O)OC[C@@H]4O3)c2n |&1:8,9,11,18,20,32,34,41,r| |
| InChIKey | RFCBNSCSPXMEBK-VBLLSAMJNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 3',3'-cGAMP can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe 3',3'-cGAMP or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2',3'-cGAMP
Cyclic Dinucleotides · CAS: 1441190-66-4
BX-CDN-00022',3'-cGAMP sodium salt
Cyclic Dinucleotides · CAS: 2734858-36-5
BX-CDN-00032'3'-c-di-AM(PS)2 (Rp,Rp) disodium salt
Cyclic Dinucleotides · CAS: 1638750-95-4
BX-CDN-00052'3'-c-di-AM(PS)2 (Rp,Rp) ammonium salt
Cyclic Dinucleotides · CAS: 1638750-96-5
BX-CDN-00062'3'-c-di-AM(PS)2 (Rp,Rp)
Cyclic Dinucleotides · CAS: 1638241-89-0
BX-CDN-0007c-di-AMP disodium salt
Cyclic Dinucleotides · CAS: 2734909-87-4
Frequently asked questions
Can the package size for 3',3'-cGAMP be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0004 and CAS 849214-04-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response
