Bz-protected Nucleosides
4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U
Quick view. We supply 4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U as a protected 2'-O-methyl nucleoside precursor for modified RNA and oligonucleotide monomer synthesis. CAS 2982811-94-7. Catalog target purity: ≥95%.
Product profile
4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U is classified as nucleoside or protected nucleoside intermediate.
4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- CAS 2982811-94-7
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Bz-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0025 and CAS 2982811-94-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Bz-protected Nucleosides product family and its named chemistry.