Coupling Activators
5-Benzylthio-1H-tetrazole (BTT)
Quick view. A benzylthio-substituted tetrazole activator used for rapid phosphoramidite coupling. CAS 21871-47-6. Catalog target purity: ≥98%.
Product profile
5-Benzylthio-1H-tetrazole (BTT) is classified as phosphoramidite coupling activator (Formula C8H8N4S; molecular weight 192.24).
5-Benzylthio-1H-tetrazole (BTT) — Activation of standard and modified phosphoramidites in automated oligonucleotide synthesis.
For 5-Benzylthio-1H-tetrazole (BTT), reported solubility: DMSO (Slightly), Methanol (Slightly). Storage: -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 5-BENZYLMERCAPTO-1H-TETRAZOLE
- 5-BENZYLMERCAPTOTETRAZOLE
- 5-[(PHENYLMETHYL)THIO]-1H-TETRAZOLE
- BMT
- BTT
- BMT: 5-BENZYLMERCAPTOTETRAZOLE
- BMT=AktivatorfdieOligonukleotidsynthese
- 5-[((phenylmethyl)thio)thio]-1H-Tetrazole
Useful catalog search terms
- CAS 21871-47-6
- Phosphoramidite coupling activator
- Coupling Activators
- Stereopure PS Reagents & Activators (PSI-ψ / CMPT)
Physicochemical data
| Melting point | 135-138°C |
|---|---|
| Boiling point | 389.3±35.0 °C(Predicted) |
| Density | 1.38 |
| pKa | 3.94±0.24(Predicted) |
| Form | Solid |
| Color | clear |
| SMILES | N1=C(SCC2=CC=CC=C2)N=NN1 |
| InChI | InChI=1S/C8H8N4S/c1-2-4-7(5-3-1)6-13-8-9-11-12-10-8/h1-5H,6H2,(H,9,10,11,12) |
| InChIKey | GXGKKIPUFAHZIZ-UHFFFAOYSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Coupling-condition development where a stronger tetrazole-family activator is preferred.
Related products
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BX-PSR-0003Benzimidazolium Triflate (BIT)
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Frequently asked questions
Can the package size for 5-Benzylthio-1H-tetrazole (BTT) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CA-0036 and CAS 21871-47-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Benzylthio-1H-tetrazole (BTT) or the named structural feature represented by this product.