Halogenated Nucleosides
5-Fluoro-4'-thiouridine
Quick view. A uridine analogue bearing fluorine at nucleobase C5 and sulfur in place of the sugar-ring oxygen at the 4'-thio position. CAS 56527-42-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-Fluoro-4'-thiouridine is classified as 5-fluoro-4'-thio uridine analogue (Formula C9H11FN2O5S; molecular weight 278.26 g/mol).
5-Fluoro-4'-thiouridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Fluoro-4'-thiouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- Uridine, 5-fluoro-4'-thio-
Useful catalog search terms
- 56527-42-5
- PubChem CID 20871287
Physicochemical data
| PubChem CID | 20871287 |
|---|---|
| InChI | InChI=1S/C9H11FN2O5S/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17) |
| InChIKey | FLAHATSCJQFZKB-UHFFFAOYSA-N |
| SMILES | O=c1nc(O)c(F)cn1C1SC(CO)C(O)C1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Fluoro-4'-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 5-Fluoro-4'-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0244 and CAS 56527-42-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.