Modified Nucleosides
5-Hydroxy-2'-deoxyuridine
Quick view. We supply 5-Hydroxy-2'-deoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 5168-36-5. Catalog target purity: Specification on request.
Product profile
5-Hydroxy-2'-deoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H12N2O6; molecular weight 244.2).
5-Hydroxy-2'-deoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Hydroxy-2'-deoxyuridine, reported solubility: Methanol (Slightly, Heated, Sonicated), Water (Slightly). Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 1-(2-Deoxypentofuranosyl)-4,5-dihydroxypyrimidin-2(1H)-one
- 5-OHdU
- Oh-5-du
- 2'-Deoxy-5-hydroxyuridine
- 2'-DEOXY-5-HYDROXY-D-URIDINE
- Uridine, 2'-deoxy-5-hydroxy-
Useful catalog search terms
- CAS 5168-36-5
- Nucleoside or protected nucleoside intermediate
- fluorescent label
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | fluorescent label |
|---|---|
| InChI | InChI=1S/C9H12N2O6/c12-3-6-4(13)1-7(17-6)11-2-5(14)8(15)10-9(11)16/h,4,6-7,12-14H,1,3H2,(H,10,15,16) |
| InChIKey | UIJSURSVLVISBO-UHFFFAOYSA-N |
| SMILES | O=c1nc(O)c(O)cn1C1CC(O)C(CO)O1 |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Fluorescent labels enable non-radioactive detection and can reduce downstream staining or secondary-label steps.
Method limitations
- Dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
These points describe 5-Hydroxy-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Hydroxy-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0578 and CAS 5168-36-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Hydroxy-2'-deoxyuridine or the named structural feature represented by this product.