Halogenated Nucleosides
5-Iodo-2'-O-methylcytidine
Quick view. A cytidine analog bearing a 5-iodo base modification and a 2'-O-methyl sugar modification, identified by CAS 847650-69-5. CAS 847650-69-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-Iodo-2'-O-methylcytidine is classified as halogenated nucleosides (Formula C10H14IN3O5; molecular weight 383.14).
5-Iodo-2'-O-methylcytidine supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 5-Iodo-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- CAS 847650-69-5
- PubChem CID 68768358
Physicochemical data
| PubChem CID | 68768358 |
|---|---|
| InChIKey | JQWRBXTVVLSBBM-JXOAFFINSA-N |
| Nucleoside scaffold | cytidine |
| Base modification | 5-iodo |
| Sugar modification | 2'-O-methyl |
| Free hydroxyls | 3'-OH and 5'-OH |
| InChI | InChI=1S/C10H14IN3O5/c1-18-7-6(16)5(3-15)19-9(7)14-2-4(11)8(12)13-10(14)17/h2,5-7,9,15-16H,3H2,1H3,(H2,12,13,17)/t5-,6-,7-,9-/m1/s1 |
| SMILES | CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(I)c(=N)nc1O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5-Iodo-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Iodo-2'-O-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-HN-0259 and CAS 847650-69-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Halogenated Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.