Intermediates
5-Iodouracil
Quick view. We supply 5-Iodouracil as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 696-07-1. Catalog target purity: Specification on request.
Product profile
5-Iodouracil is classified as specialty research-use chemical building block (Formula C4H3IN2O2; molecular weight 237.98).
5-Iodouracil is a halogenated pyrimidine that can be used in nucleoprotein photo-crosslinking via RNA substitution. 5-Iodouracil is used in thymidine phosphorylase targeted imaging and therapy. Studie s show that DNA N-glycosylase MED1 exhibited higher preference for 5-Iodouracil and halogenated bases over non-halogenated ones.
For 5-Iodouracil, reported solubility: Very faint turbidity in NH3aq. Soluble in 1M NaOH. Storage: 0-6°C.
Names and search terms
Confirmed or normalized name variants
- 2,4-DIHYDROXY-5-IODOPYRIMIDINE
- 5-IODO-1H-PYRIMIDINE-2,4-DIONE
- 5-IODO-2,4-(1H,3H)-PYRIMIDINEDIONE
- 5IU
- TIMTEC-BB SBB009920
- 3h)-pyrimidinedione,5-iodo-4(1h
- 5-iodo-uraci
- 2,4(1H,3H)-Pyrimidinedione, 5-iodo-
Useful catalog search terms
- CAS 696-07-1
- Specialty research-use chemical building block
- Intermediates
Physicochemical data
| InChI | InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
|---|---|
| InChIKey | KSNXJLQDQOIRIP-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(I)C(=O)N1 |
| Melting point | 274-276 °C (dec.) (lit.) |
| Density | 2.2076 (estimate) |
| pKa | 7.02±0.10(Predicted) |
| Form | Fluffy Powder |
| Color | White to light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5-Iodouracil can be used as a defined research input for chemistry feasibility, analytical method development and material comparison.
- Typical qualification includes identity, purity method, storage, handling and downstream workflow compatibility.
- Related analogs, impurity standards and custom quantities can be reviewed for project-specific research needs.
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Frequently asked questions
Can the package size for 5-Iodouracil be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-INTE-0092 and CAS 696-07-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.