Other Modified Nucleosides
5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG
Quick view. We supply 5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG as a 5'-vinylphosphonate guanosine analog for stable phosphate-mimic oligonucleotide research. A public CAS number is not assigned for this exact form. Catalog target purity: Specification on request.
Product profile
5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG is classified as nucleoside or protected nucleoside intermediate.
5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Useful catalog search terms
- Nucleoside or protected nucleoside intermediate
- Other Modified Nucleosides
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-NH₂-2'-dA
Other Modified Nucleosides · CAS: 132471-87-5
BX-MN-00113'-O-NH₂-2'-dC
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BX-MN-00123'-O-NH₂-2'-dG
Other Modified Nucleosides · CAS: 132471-91-1
BX-MN-00133'-O-NH₂-2'-dT
Other Modified Nucleosides · CAS: 103251-38-3
BX-MN-00143'-O-Phthalimido-2'-dA
Other Modified Nucleosides · CAS: 132471-93-3
BX-MN-00153'-O-Phthalimido-2'-dG
Other Modified Nucleosides · CAS: 1263039-35-5
Frequently asked questions
Can the package size for 5'-Me-(E)-vinyl phosphonate-3'-O-Me-rG be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0019, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Other Modified Nucleosides product family and its named chemistry.