DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rA(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-Me-rA(Bz) as a DMTr-protected 2'-O-methyl nucleoside used as a precursor to 2'-OMe amidites, supports and modified RNA building blocks. CAS 110764-72-2. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-O-Me-rA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C39H37N5O7; molecular weight 687.74).
5'-O-DMTr-2'-O-Me-rA(Bz) — DMT-OMe-rA(Bz) is a nucleoside analog.
For 5'-O-DMTr-2'-O-Me-rA(Bz), reported solubility: Soluble in chloroform at 50mg/ml. Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-OMe-Bz-A
- DMTr-2'-OMe-ABz
- -9H-purin-6-yl)
- DMT-2'-OMe-Bz-dA
- 5'-DMT-2'-OMe-Bz-A
- N-(9-((2R,3R,4R,5R)
- N6-Bz-DMT-2'-OMe-Ar
- 5'-O-DMT-N6-Benzoyl-2'-OMe-adenosine
Useful catalog search terms
- CAS 110764-72-2
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| pKa | 7.87±0.43(Predicted) |
| Form | Powder |
| Color | White to Pale Yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-Me-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rG(iBu)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00193'-O-DMTr-2'-O-Me-rU
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00203'-O-DMTr-dA(Bz)
DMTr-protected Nucleosides · CAS: 140712-79-4
BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00275'-O-DMTr-2'-O-(2-aminoethyl) -5-Me-rU
DMTr-protected Nucleosides · CAS: 242147-79-1
BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
DMTr-protected Nucleosides · CAS: 863408-41-7
Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0065 and CAS 110764-72-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.