DMTr-protected Nucleosides
5'-O-DMTr-2'-O-MOE-5-Me-rU
Quick view. 5-Methyluridine bearing a 5'-O-DMTr group, a 2'-O-(2-methoxyethyl) substituent and a free 3'-hydroxyl. CAS 163759-50-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-O-MOE-5-Me-rU is classified as dmtr-protected nucleosides (Formula C34H38N2O9; molecular weight 618.67).
5'-O-DMTr-2'-O-MOE-5-Me-rU is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 5'-O-DMTr-2'-O-MOE-5-Me-rU, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-(2-methoxyethyl)-5-methyluridine
- DMT-2'-O-MOE-T
Useful catalog search terms
- CAS 163759-50-0
Physicochemical data
| Nucleoside | 5-methyluridine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' hydroxyl group unprotected |
| InChI | InChI=1S/C34H38N2O9/c1-22-20-36(33(39)35-31(22)38)32-30(43-19-18-40-2)29(37)28(45-32)21-44-34(23-8-6-5-7-9-23,24-10-14-26(41-3)15-11-24)25-12-16-27(42-4)17-13-25/h5-17,20,28-30,32,37H,18-19,21H2,1-4H3,(H,35,38,39)/t28-,29-,30-,32-/m1/s1 |
| InChIKey | WIPCVBQXKBWNRC-PBAMLIMUSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OCCOC |
| PubChem CID | 15864049 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-5-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-5-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0038 and CAS 163759-50-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.