DMTr-protected Nucleosides
5'-O-DMTr-2'-O-MOE-rA(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-MOE-rA(Bz) as a protected MOE adenosine intermediate for ASO and modified RNA monomer preparation. CAS 251647-48-0. Catalog target purity: ≥98%.
Product profile
5'-O-DMTr-2'-O-MOE-rA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C41H41N5O8; molecular weight 731.79).
5'-O-DMTr-2'-O-MOE-rA(Bz) — N-Benzoyl-5''-O-[bis(4-methoxyphenyl)phenylmethyl]-2''-O-(2-methoxyethyl)-adenosine is a commonly used reactant in the preparation of nucleosidic phosphoramidite derivatives.
For 5'-O-DMTr-2'-O-MOE-rA(Bz), reported solubility: Acetonitrile (Sparingly), Chloroform (Slightly), DMF (Slightly, Sonicated), DMSP. Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-2'-O-MOE-N6-Bz-rA
- 5'-DMTr-2'-MOE-N6-Bz-Adenosine
- 5'-O-DMT-N6-Bz-2'-MOE-Adenosine
- N-benzoyl-5'-O-DMTr-2'-O-(2-Methoxyethyl)-Adenosine
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)adenosine
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)adenosine
- Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-
- 5'-O-DMT-2'-O-MOE-rA(Bz)
Useful catalog search terms
- CAS 251647-48-0
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-MOE modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification |
|---|---|
| Melting point | 95 - 98°C |
| Density | 1.31 |
| pKa | 7.87±0.43(Predicted) |
| Form | Solid |
| Color | Off-White to Pale Yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](OCCOC)[C@@H]1O |&1:25,27,46,52,r| |
| InChIKey | KEVMXGNDTKPSMC-AASGFKNJNA-N |
| InChI | InChI=1S/C41H41N5O8/c1-49-22-23-52-36-35(47)33(54-40(36)46-26-44-34-37(42-25-43-38(34)46)45-39(48)27-10-6-4-7-11-27)24-53-41(28-12-8-5-9-13-28,29-14-18-31(50-2)19-15-29)30-16-20-32(51-3)21-17-30/h4-21,25-26,33,35-36,40,47H,22-24H2,1-3H3,(H,42,43,45,48)/t33-,35-,36-,40-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-MOE-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0039 and CAS 251647-48-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.