DMTr-protected Nucleosides
5'-O-DMTr-2'-O-TBDMS-rA(Bz)
Quick view. We supply 5'-O-DMTr-2'-O-TBDMS-rA(Bz) as a classic protected adenosine intermediate for RNA phosphoramidite synthesis. CAS 81265-93-2. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-TBDMS-rA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C44H49N5O7Si; molecular weight 787.97).
5'-O-DMTr-2'-O-TBDMS-rA(Bz) — 5''-O-DMT-2''-O-TBDMS-N-Bz-Adenosine (CAS# 81265-93-2) is a fluorescent adenosine-containing compound which is often used in for DNA/RNA modifications for detection or the addition of synthetic oligonucleotide blocks.
For 5'-O-DMTr-2'-O-TBDMS-rA(Bz), storage: 2-8°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 5'-DMT-2'-TBDMS-Bz-rA
- 5'-O-DMT-2'-O-TBDMS-Bz-rA
- 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
- 2'-O-TBDMS-5'-O-DMT-N6-Bz adenosine
- N6-Bz-2'-O-TBDMS-5'-O-DMT-adenosine
- 5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-Adenosine
- N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine
- 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N6-benzoyl adenosine
Useful catalog search terms
- CAS 81265-93-2
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- TBDMS protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection |
|---|---|
| Density | 1.23±0.1 g/cm3(Predicted) |
| pKa | 7.87±0.43(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1O |&1:25,27,46,55,r| |
| InChIKey | DAZIGOPASNJPCJ-OLXVHECFNA-N |
| InChI | InChI=1S/C44H49N5O7Si/c1-43(2,3)57(6,7)56-38-37(50)35(55-42(38)49-28-47-36-39(45-27-46-40(36)49)48-41(51)29-14-10-8-11-15-29)26-54-44(30-16-12-9-13-17-30,31-18-22-33(52-4)23-19-31)32-20-24-34(53-5)25-21-32/h8-25,27-28,35,37-38,42,50H,26H2,1-7H3,(H,45,46,48,51)/t35-,37-,38-,42-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-TBDMS-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-TBDMS-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0042 and CAS 81265-93-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.