Other Phosphoramidites
5'-O-DMTr-2'-OMeU-methyl phosphonamidite
Quick view. We supply 5'-O-DMTr-2'-OMeU-methyl phosphonamidite as a specialty phosphoramidite for nonstandard oligonucleotide modification. CAS 191786-64-8. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
5'-O-DMTr-2'-OMeU-methyl phosphonamidite is classified as protected oligonucleotide phosphoramidite building block (Formula C38H48N3O8P; molecular weight 705.79).
5'-O-DMTr-2'-OMeU-methyl phosphonamidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 5'-O-DMTr-2'-OMeU-methyl phosphonamidite, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2'-O-methyluridine-3'-O-(P-methyl-N,N-diisopropylamino)phosphomidite
- 5'-O-DMT-2'-OMeU-methyl phosphonamidite
Useful catalog search terms
- CAS 191786-64-8
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-methyl modification
- phosphoramidite coupling group
- Other Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-OMeU-methyl phosphonamidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-OMeU-methyl phosphonamidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0094 and CAS 191786-64-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry.