DMTr-protected Nucleosides
5'-O-DMTr-3'-O-Me-rA(Bz)
Quick view. We supply 5'-O-DMTr-3'-O-Me-rA(Bz) as a DMTr-protected nucleoside intermediate for selective oligonucleotide building-block synthesis. CAS 127212-38-8. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-3'-O-Me-rA(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C39H37N5O7; molecular weight 687.74).
5'-O-DMTr-3'-O-Me-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-3'-O-Me-rA(Bz), the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-5'-O-DMT-3'-O-methyladenosine
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-methyl adenosine
- Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-methyl-
- 5'-O-DMT-3'-O-Me-rA(Bz)
Useful catalog search terms
- CAS 127212-38-8
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 5'-O-DMTr-3'-O-Me-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-3'-O-Me-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0078 and CAS 127212-38-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.