Modified Nucleosides
8-Nitroguanosine
Quick view. We supply 8-Nitroguanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 337536-53-5. Catalog target purity: Specification on request.
Product profile
8-Nitroguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C10H12N6O7; molecular weight 328.24).
8-Nitroguanosine — A highly reactive redox-active nucleic acid derivative that is formed in cellular RNA as biomarker of exposure to reactive nitrogen species. Recent studies suggest that it might contribute to the pathogenesis of inflammation-associated carcinogenesis.
For 8-Nitroguanosine, reported solubility: DMSO (Slightly), Methanol(Slightly), Water (Slightly, Heated, Sonicated). Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 8-Nitro-D-guanosine
Useful catalog search terms
- CAS 337536-53-5
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C10H12N6O7/c11-9-13-6-3(7(20)14-9)12-10(16(21)22)15(6)8-5(19)4(18)2(1-17)23-8/h,4-5,8,17-19H,1H2,(H3,11,13,14,20)/t2-,4-,5-,8-/m1/s |
|---|---|
| InChIKey | KGUOMRFOXYDMAH-UMMCILCDSA-N |
| SMILES | C([C@@H]1[C@H]([C@H]([C@@H](O1)N2C3=C(C(=O)N=C(N3)N)N=C2[N+](=O)[O-])O)O)O |
| Boiling point | 841.0±75.0 °C(Predicted) |
| Density | 2.50±0.1 g/cm3(Predicted) |
| pKa | 12.90±0.70(Predicted) |
| Form | Solid |
| Color | Orange to Dark Orange |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 8-Nitroguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosylmethionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-0185(R-/S-) 5-Carbamoylhydroxy methyluridine
Modified Nucleosides · CAS: N/A
BX-MN-0186(R-/S-)5-(1-Hydroxy)(methoxycarbonyl)methyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0187(R-/S-)5-Carboxyhydroxymethyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0719(R)-N-(2,3-dihydro-1H-indenyl)adenosine
Modified Nucleosides · CAS: 96392-15-3
Frequently asked questions
Can the package size for 8-Nitroguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0483 and CAS 337536-53-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.