cEt-BNA
BNA(N-Me)-A(Bz)-CE-Phosphoramidite
Quick view. We supply BNA(N-Me)-A(Bz)-CE-Phosphoramidite as a constrained ethyl BNA phosphoramidite for high-affinity therapeutic oligonucleotide synthesis. CAS 1247023-38-6. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
BNA(N-Me)-A(Bz)-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
BNA(N-Me)-A(Bz)-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For BNA(N-Me)-A(Bz)-CE-Phosphoramidite, high-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
Names and search terms
Confirmed or normalized name variants
- BNA(N-Me)-A(Bz)-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 1247023-38-6
- Protected oligonucleotide phosphoramidite building block
- conformationally locked sugar
- phosphoramidite coupling group
- cEt-BNA
Physicochemical data
| Key chemistry motifs | conformationally locked sugar; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe BNA(N-Me)-A(Bz)-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for BNA(N-Me)-A(Bz)-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CB-0006 and CAS 1247023-38-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss BNA(N-Me)-A(Bz)-CE-Phosphoramidite or the named structural feature represented by this product.