LNA Phosphoramidites
DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite as an LNA adenosine monomer for increasing affinity and nuclease resistance in oligonucleotides. CAS 206055-79-0. Catalog target purity: ≥97%.
Product profile
DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C48H52N7O8P; molecular weight 885.96).
DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite, storage: Store at -20°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- DMTr-LNA-A(Bz)-3-CED-phosphoramidite
- N6-Bz-2'-O-4'-C-Locked-Ar-CE-Phosphoramidite
- N6-Bz-2'-O-4'-A-Locked-Ar-CE-Phosphoramidite
- DMT-locA(bz) Phosphoramidite configured for ABI
- DMT-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite
- DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-2-cyanoethyl phosphoramidite
- LNA-A(Bz)-Phosphoramidite
- BX-LP-0017
Useful catalog search terms
- CAS 206055-79-0
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- LNA Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| SMILES | C([C@@]12CO[C@@H]([C@H](N3C=NC4C(=NC=NC3=4)NC(C3C=CC=CC=3)=O)O1)C2([H])OP(OCCC#N)N(C(C)C)C(C)C)OC(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)C1C=CC(OC)=CC=1 |&1:1,4,5,r| |
| InChIKey | HPIDKMAOZZZGOP-IMIAKKHCNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
DMTr-2'-O-4'-C-Locked- rC(Ac)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0002DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0003DMTr-2'-O-4'-C-Locked-5-Me-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-82-5
BX-LP-0005DMTr-2'-O-4'-C-Locked-rC(Bz)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: N/A
BX-LP-0006DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 709641-79-2
BX-LP-0007DMTr-2'-O-4'-C-Locked-rG(iBu)-3'-CE-Phosphoramidite
LNA Phosphoramidites · CAS: 206055-77-8
Frequently asked questions
Can the package size for DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-LP-0004 and CAS 206055-79-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-4'-C-Locked-rA(Bz)-3'-CE-Phosphoramidite or the named structural feature represented by this product.