2'-O-MOE Phosphoramidites
DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite
Quick view. We supply DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite as a specialty MOE adenosine amidite for modified phosphoramidite route development. A public CAS number is not assigned for this exact form. Catalog target purity: ≥95%.
Product profile
DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite is classified as protected oligonucleotide phosphoramidite building block.
DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite, dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite
Useful catalog search terms
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-O-MOE modification
- fluorescent label
- phosphoramidite coupling group
- 2'-O-MOE Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification; fluorescent label; phosphoramidite coupling group |
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Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Fluorescent labels enable non-radioactive detection and can reduce downstream staining or secondary-label steps.
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- Dye-labeled nucleotides or amidites are bulkier than native monomers; incorporation efficiency, label density, photobleaching and light exposure should be controlled.
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2OMP-0003DMTr-2'-O-MOE-5-Me-rC(DMTr)-3'-CE-Phosphoramidite
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BX-2OMP-0005DMTr-2'-O-MOE-rA(Bz)-3'- ((2-cyanoethoxy)(diisopropylamino) phosphoramidite)-ethyl-diisopropylphosphoramidite
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BX-2OMP-0007DMTr-2'-O-MOE-rA(DMTr)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMP-0006, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-2'-O-MOE-rA(Bz)-3'-CE-(1-hydroxy-N,N-diisopropyl)phosphoramidite or the named structural feature represented by this product.