RNA (2'-O-TBDMS) Phosphoramidites
DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite as a standard acetyl-protected cytidine monomer for RNA solid-phase synthesis. CAS 121058-88-6. Catalog target purity: Specification on request.
Product profile
DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H64N5O9PSi; molecular weight 902.1).
DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite — DMT-2′O-TBDMS-rC(ac) Phosphoramidite was used for inverse electron-demand Diels-Alder reactions for selective and efficient labeling of RNA.
For DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite, reported solubility: DMSO: 100 mg/mL (110.85 mM). Storage: Sealed in dry,Store in freezer, under -20°C.
Names and search terms
Confirmed or normalized name variants
- 2'-TBDMS-C CEP
- Ac-rC Phosphoramidite
- 2’-TBDMS-rC(N-Ac) Phosphoramidite
- 2'-TBDMS -Ac-rC-CE-Phosphoramidite
- 5'-O-DMT-2'-TBDMS-rC(N-Ac)-3'-CEDPA
- DMT-2′O-TBDMS-rC(ac) Phosphoramidite
- 5'-DMT-2'-TBDMS-rC(N-Ac) Phosphoramidite
- REF DUPL: 2'-TBDMS-rC(N-ac) Phosphoramidite
Useful catalog search terms
- CAS 121058-88-6
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- TBDMS protection
- phosphoramidite coupling group
- 2'-O-TBDMS-rC(Ac) Phosphoramidite
- BX-R2OT-0011
- RNA (2'-O-TBDMS) Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; TBDMS protection; phosphoramidite coupling group |
|---|---|
| Form | powder |
| Color | white to off-white |
| InChIKey | QKWKXYVKGFKODW-UMIUEWJMNA-N |
| InChI | InChI=1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m0/s |
| SMILES | COc1ccc(C(OC[C@@H]2O[C@H](n3ccc(NC(C)=O)nc3=O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
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Frequently asked questions
Can the package size for DMTr-2'-O-TBDMS-rC(Ac)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-R2OT-0025 and CAS 121058-88-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the RNA (2'-O-TBDMS) Phosphoramidites product family and its named chemistry.