GalNAc
GalNAc-L96-Phosphoramidite
Quick view. We supply GalNAc-L96-Phosphoramidite as a triantennary GalNAc amidite for direct installation on oligonucleotides. CAS 1159408-62-4. Catalog target purity: Specification on request.
Product profile
GalNAc-L96-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C121H179N11O45.C6H15N; molecular weight 2608.96).
GalNAc-L96-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For GalNAc-L96-Phosphoramidite, reported solubility: Acetonitrile: Soluble. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- L96.TEA
- GalnAc-L96 TEA
- BX-GALN-0039
Useful catalog search terms
- CAS 1159408-62-4
- Protected oligonucleotide phosphoramidite building block
- GalNAc ligand motif
- phosphoramidite coupling group
- GalNAc-L96 Phosphoramidite
- GalNAc
Physicochemical data
| Key chemistry motifs | GalNAc ligand motif; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | Off-white to light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
- GalNAc-L96 Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
Product-specific evaluation notes
Potential advantages
- A defined GalNAc intermediate helps decouple ligand-linker optimization from sequence optimization.
Method limitations
- In-vitro affinity and in-vivo delivery behavior may diverge; valency, linker length and conjugation site need empirical confirmation.
These points describe GalNAc-L96-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for GalNAc-L96-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-GALN-0020 and CAS 1159408-62-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss GalNAc-L96-Phosphoramidite or the named structural feature represented by this product.