Modified Nucleosides
N-Methylguanosine
Quick view. We supply N-Methylguanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 2140-77-4. Catalog target purity: Specification on request.
Product profile
N-Methylguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O5; molecular weight 297.27).
N-Methylguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N-Methylguanosine, reported solubility: DMSO: 7.69 mg/mL (25.87 mM; Need ultrasonic)|. Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- N(2)-methylguanosine
- m2G
- 2-Methylguanosine
- Guanosine, N-methyl-
- 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-methylamino-3H-purin-6-one
Useful catalog search terms
- CAS 2140-77-4
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10-/m1/s |
|---|---|
| InChIKey | SLEHROROQDYRAW-KQYNXXCUSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC)=O)N=C2)[C@H](O)[C@@H]1O |
| Melting point | 233 °C (decomp)(Solv: water (7732-18-5)) |
| Density | 2.00±0.1 g/cm3(Predicted) |
| pKa | 9.87±0.20(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosylmethionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-0185(R-/S-) 5-Carbamoylhydroxy methyluridine
Modified Nucleosides · CAS: N/A
BX-MN-0186(R-/S-)5-(1-Hydroxy)(methoxycarbonyl)methyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0187(R-/S-)5-Carboxyhydroxymethyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0719(R)-N-(2,3-dihydro-1H-indenyl)adenosine
Modified Nucleosides · CAS: 96392-15-3
Frequently asked questions
Can the package size for N-Methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0377 and CAS 2140-77-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.