Modified Nucleosides
N1-Methylguanosine
Quick view. We supply N1-Methylguanosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 2140-65-0. Catalog target purity: ≥95%.
Product profile
N1-Methylguanosine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15N5O5; molecular weight 297.27).
N1-Methylguanosine-CD3 is the labeled form of N1-Methylguanosine, which ic use in methods for increasing capping efficiency of transcribed RNA.
For N1-Methylguanosine, reported solubility: Soluble in water; confirm lot-specific concentration limits. Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- 1-methylguanosine
- Nsc 70897
- Guanosine, 1-methyl-
- RNA-modified nucleoside m1G
- Guanosine, 1-methyl- (8ci)(9ci)
- 1-Methyl-2-amino-9-β-D-ribofuranosyl-9H-purine-6(1H)-one
Useful catalog search terms
- CAS 2140-65-0
- Nucleoside or protected nucleoside intermediate
- Modified Nucleosides
Physicochemical data
| Melting point | 142 °C |
|---|---|
| SMILES | CN1C(=O)C2=C(N=C1N)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O |
| InChIKey | UTAIYTHAJQNQDW-KQYNXXCUSA-N |
| InChI | InChI=1S/C11H15N5O5/c1-15-9(20)5-8(14-11(15)12)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14)/t4-,6-,7-,10-/m1/s |
| Boiling point | 737.4±70.0 °C(Predicted) |
| Density | 2.02±0.1 g/cm3(Predicted) |
| pKa | 13.22±0.70(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- N1-Methylguanosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for N1-Methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0743 and CAS 2140-65-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.