Modified Nucleosides
N6,N6-Dimethyl-2'-O-methyladenosine
Quick view. We supply N6,N6-Dimethyl-2'-O-methyladenosine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 30891-53-3. Catalog target purity: Specification on request.
Product profile
N6,N6-Dimethyl-2'-O-methyladenosine is classified as nucleoside or protected nucleoside intermediate (Formula C13H19N5O4; molecular weight 309.32).
N6,N6-Dimethyl-2'-O-methyladenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N6,N6-Dimethyl-2'-O-methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N,N-Dimethyl-2'-O-methyladenosine
- N6,N6,2'-O-Trimethyladenosine
- Adenosine, N,N-dimethyl-2'-O-methyl-
- RNA-modified nucleoside m62Am
Useful catalog search terms
- CAS 30891-53-3
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C13H19N5O4/c1-17(2)11-8-12(15-5-14-11)18(6-16-8)13-10(21-3)9(20)7(4-19)22-13/h5-7,9-10,13,19-20H,4H2,1-3H3/t7-,9-,10-,13-/m1/s |
| InChIKey | IPRQAJTUSRLECG-QYVSTXNMSA-N |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6,N6-Dimethyl-2'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
(S)-cEt-rA
Modified Nucleosides · CAS: 1197033-34-3
BX-OP-0069S-Adenosylmethionine (SAM)
Modified Nucleosides · CAS: 485-80-3
BX-MN-0185(R-/S-) 5-Carbamoylhydroxy methyluridine
Modified Nucleosides · CAS: N/A
BX-MN-0186(R-/S-)5-(1-Hydroxy)(methoxycarbonyl)methyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0187(R-/S-)5-Carboxyhydroxymethyl uridine
Modified Nucleosides · CAS: N/A
BX-MN-0719(R)-N-(2,3-dihydro-1H-indenyl)adenosine
Modified Nucleosides · CAS: 96392-15-3
Frequently asked questions
Can the package size for N6,N6-Dimethyl-2'-O-methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0798 and CAS 30891-53-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.