2'-F Nucleosides
2',5'-Dideoxy-2'-fluoro-5'-iodouridine
Quick view. We supply 2',5'-Dideoxy-2'-fluoro-5'-iodouridine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 211694-25-6. Catalog target purity: Specification on request.
Structure confirmation
This item requires structure confirmation before quotation. Send the target structure, CAS number, SMILES, InChI or drawing for our technical review.
Canonical name plus a structure drawing, SMILES, InChI or unambiguous CAS number.
Protecting groups, stereochemistry, salt or counterion, hydration and requested form.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2',5'-Dideoxy-2'-fluoro-5'-iodouridine is classified as nucleoside or protected nucleoside intermediate.
2',5'-Dideoxy-2'-fluoro-5'-iodouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2',5'-Dideoxy-2'-fluoro-5'-iodouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Useful catalog search terms
- CAS 211694-25-6
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2',5'-Dideoxy-2'-fluoro-5'-iodouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',5'-Dideoxy-2'-fluoro-5'-iodouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0109 and CAS 211694-25-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.