Amino-modified Nucleosides
3'-Azido-2',3'-dideoxyuridine
Quick view. We supply 3'-Azido-2',3'-dideoxyuridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 84472-85-5. Catalog target purity: Specification on request.
Product profile
3'-Azido-2',3'-dideoxyuridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H11N5O4; molecular weight 253.21).
3'-Azido-2',3'-dideoxyuridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-Azido-2',3'-dideoxyuridine, reported solubility: DMSO (Slightly), Methanol (Very Slightly). Storage: −20°C.
Names and search terms
Confirmed or normalized name variants
- navuridine
- CS-87
- AzddU
- AzUrd
- 3'-N3-ddU
- 3'-Az-ddU
- NSC 380882
- 3'-Azido-ddU, AZDU, AzddU
Useful catalog search terms
- CAS 84472-85-5
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1/C9H11N5O4/c10-13-12-5-3-8(18-6(5)4-15)14-2-1-7(16)11-9(14)17/h1-2,5-6,8,15H,3-4H2,(H,11,16,17)/t5-,6-,8-/s |
| InChIKey | ZSNNBSPEFVIUDS-MWZMYLSLNA-N |
| SMILES | N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](CO)[C@H](N=[N+]=[N-])C1 |&1:8,10,13,r| |
| Melting point | 166-167℃ |
| Form | Solid |
| Color | White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 3'-Azido-2',3'-dideoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Azido-2',3'-dideoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0236 and CAS 84472-85-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-Azido-2',3'-dideoxyuridine or the named structural feature represented by this product.