Amino-modified Nucleosides
3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine
Quick view. We supply 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 29706-84-1. Catalog target purity: Specification on request.
Product profile
3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C29H27N5O4; molecular weight 509.563).
3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine, reported solubility: Chloroform (Sparingly), Methanol (Slightly). Form: Solid.
Names and search terms
Confirmed or normalized name variants
- 1-[(2R,4S,5S)-4-azido-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- 5'-Trt-Zidovudine
- 5'-O-Trt-Zidovudine
- Zidovudine impurity Q
- Trityl Azido Thymidine
- Zidovudine EP Impurity J
- 3-Azido-3-deoxy-5-O-triphe
- 3''-AZIDO-3''-DEOXY-5''-O-TRITYLTHYMIDINE
Useful catalog search terms
- CAS 29706-84-1
- Nucleoside or protected nucleoside intermediate
- azide click handle
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | azide click handle; amine functionality |
|---|---|
| InChI | InChI=1S/C29H27N5O4/c1-20-18-34(28(36)31-27(20)35)26-17-24(32-33-30)25(38-26)19-37-29(21-11-5-2-6-12-21,22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,18,24-26H,17,19H2,1H3,(H,31,35,36)/t24-,25+,26+/m0/s |
| InChIKey | AZPSSDWPMSICSH-JIMJEQGWSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)N=[N+]=[N-] |
| Melting point | 103-104 °C(Solv: toluene (108-88-3)) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Click-compatible handles separate oligonucleotide synthesis from late-stage labeling, which helps screen multiple payloads from a common intermediate.
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Copper-catalyzed, copper-free or inverse-electron-demand click conditions can affect sensitive oligonucleotides differently; residual metal, solvent and purification strategy should be controlled.
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0197 and CAS 29706-84-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 3'-Azido-5'-O-trityl-2',3'-dideoxy-5-methyluridine or the named structural feature represented by this product.