Amino-modified Nucleosides
5-(Methylaminomethyl)-2-thiouridine
Quick view. We supply 5-(Methylaminomethyl)-2-thiouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 32860-54-1. Catalog target purity: Specification on request.
Product profile
5-(Methylaminomethyl)-2-thiouridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H17N3O5S; molecular weight 303.33).
5-(Methylaminomethyl)-2-thiouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-(Methylaminomethyl)-2-thiouridine, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- Mnm5s2U
- Uridine,5-[(methylamino)methyl]-2-thio-
- 5-(Methylamino methyl)-2-thiouridine,RNA-modified nucleoside mnm5s2U
Useful catalog search terms
- CAS 32860-54-1
- Nucleoside or protected nucleoside intermediate
- amine functionality
- Amino-modified Nucleosides
Physicochemical data
| Key chemistry motifs | amine functionality |
|---|---|
| InChI | InChI=1S/C11H17N3O5S/c1-12-2-5-3-14(11(20)13-9(5)18)10-8(17)7(16)6(4-15)19-10/h,6-8,10,12,15-17H,2,4H2,1H3,(H,13,18,20)/t6-,7-,8-,10-/m1/s |
| InChIKey | HXVKEKIORVUWDR-FDDDBJFASA-N |
| SMILES | CNCc1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=S)nc1O |
| Density | 1.58±0.1 g/cm3(Predicted) |
| pKa | 6.44±0.23(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe 5-(Methylaminomethyl)-2-thiouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-(Methylaminomethyl)-2-thiouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-AMN-0071 and CAS 32860-54-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Amino-modified Nucleosides product family and its named chemistry.