DMTr-protected Nucleosides
5'-O-DMTr-2'-O-Me-rU
Quick view. We supply 5'-O-DMTr-2'-O-Me-rU as a DMTr-protected 2'-O-methyl nucleoside used as a precursor to 2'-OMe amidites, supports and modified RNA building blocks. CAS 103285-22-9. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-O-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C31H32N2O8; molecular weight 560.59).
5'-O-DMTr-2'-O-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-DMTr-2'-O-Me-rU, reported solubility: Soluble in acetonitrile. Storage: Store dry at 2-8°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-OMe-U
- 5'-DMT-2'-OMe-U
- DMT-2'-O-METHYLURIDINE
- 5'-O-DMT-2'-O-methyluridine
- 5'-O-DMT-2'-O-methyl-D-uridine
- 5'-O-(DIMETHOXYTRITYL)-2'-O-METHYLURIDINE
- 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-uridine
Useful catalog search terms
- CAS 103285-22-9
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-methyl modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-methyl modification |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| pKa | 9.39±0.10(Predicted) |
| Form | Powder |
| Color | White to Pale Yellow |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1O |&1:25,27,36,39,r| |
| InChIKey | MFDHAVFJDSRPKC-JSEYUTSUNA-N |
| InChI | InChI=1S/C31H32N2O8/c1-37-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(38-2)16-12-22)40-19-25-27(35)28(39-3)29(41-25)33-18-17-26(34)32-30(33)36/h4-18,25,27-29,35H,19H2,1-3H3,(H,32,34,36)/t25-,27-,28-,29-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 5'-O-DMTr-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0095 and CAS 103285-22-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.