DMTr-protected Nucleosides
5'-O-DMTr-2'-O-MOE-5-Me-rU
Quick view. We supply 5'-O-DMTr-2'-O-MOE-5-Me-rU as a DMT-protected MOE thymidine/5-methyluridine intermediate for therapeutic oligonucleotide monomer synthesis. CAS 163759-50-0. Catalog target purity: ≥95%.
Product profile
5'-O-DMTr-2'-O-MOE-5-Me-rU is classified as nucleoside or protected nucleoside intermediate (Formula C34H38N2O9; molecular weight 618.67).
5'-O-DMTr-2'-O-MOE-5-Me-rU — 5''-O-DMT-2''-O-(2-methoxyethyl)-5-methyluridine is a protected uridine derivative and nucleoside used in the preparation of synthetic nucleic acids.
For 5'-O-DMTr-2'-O-MOE-5-Me-rU, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 5'-DMTr-2'-MOE-5-Me-Uridine
- 5'-O-DMT-2’-MOE-5-Methyluridine
- 5'-O-DMT-2'-O-(2-methoxyethyl)-5-methyluridine
- 5'-O-DMTr- 2'-O-(2-Methoxyethyl)-5-Methyl- uridine
- Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-met...
- 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methyluridine
- 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(2-methoxyethyl)-5-methyluridine
- 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyluridine
Useful catalog search terms
- CAS 163759-50-0
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-O-MOE modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-O-MOE modification |
|---|---|
| Density | 1.32 |
| pKa | 9.55±0.10(Predicted) |
| SMILES | O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](OCCOC)[C@@H]1O |&1:25,27,37,43,r| |
| InChIKey | WIPCVBQXKBWNRC-WUEHZYHJNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
- We release this product against the stated purity specification; the lot-specific CoA provides the result and analytical basis.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-O-MOE-5-Me-rU can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 5'-O-DMTr-2'-O-MOE-5-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-O-MOE-5-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0038 and CAS 163759-50-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.