Cyclic Dinucleotides
2',3'-cGAMP sodium salt
Quick view. We supply the sodium salt of 2',3'-cGAMP for aqueous assay preparation and cGAS-STING signaling studies. CAS 2734858-36-5. Catalog target purity: ≥99%.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2',3'-cGAMP sodium salt is classified as cyclic dinucleotide second messenger or analog (Formula C20H25N10NaO13P2; molecular weight 698.41).
2',3'-cGAMP sodium salt — 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm.
For 2',3'-cGAMP sodium salt, reported solubility: Water: Soluble. Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- 2'3'-cGAMP sodium
- 2',3'-cyclic GMP-AMP sodium salt
Useful catalog search terms
- CAS 2734858-36-5
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Counterion | Sodium |
| Supply form | Dry salt |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2',3'-cGAMP sodium salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe 2',3'-cGAMP sodium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2',3'-cGAMP
Cyclic Dinucleotides · CAS: 1441190-66-4
BX-CDN-00032'3'-c-di-AM(PS)2 (Rp,Rp) disodium salt
Cyclic Dinucleotides · CAS: 1638750-95-4
BX-CDN-00043',3'-cGAMP
Cyclic Dinucleotides · CAS: 849214-04-6
BX-CDN-00052'3'-c-di-AM(PS)2 (Rp,Rp) ammonium salt
Cyclic Dinucleotides · CAS: 1638750-96-5
BX-CDN-00062'3'-c-di-AM(PS)2 (Rp,Rp)
Cyclic Dinucleotides · CAS: 1638241-89-0
BX-CDN-0007c-di-AMP disodium salt
Cyclic Dinucleotides · CAS: 2734909-87-4
Frequently asked questions
Can the package size for 2',3'-cGAMP sodium salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0002 and CAS 2734858-36-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response