2'-F-ANA Phosphoramidites
2'-F-ANA-dG(ibu) Phosphoramidite
Quick view. We supply 2'-F-ANA-dG(ibu) Phosphoramidite as a 2'-F-ANA phosphoramidite for synthesizing fluoro-arabino modified oligonucleotides. CAS 1404463-20-2. Catalog target purity: Specification on request.
Structure and identity
The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.
CAS, molecular formula, SMILES or InChI data are shown below when available.
We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.
Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.
Product profile
2'-F-ANA-dG(ibu) Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C44H53FN7O8P; molecular weight 857.92).
2'-F-ANA-dG(ibu) Phosphoramidite — 9-(2''-Deoxy-5''-O-DMT-2''-fluoro-b-D-arabinofuranosyl)-N2-isobutyrylguanine 3''-CE phosphoramidite is a reagent used in the preparation of siRNA nanocarries that are based on methacrylic acid copolymers.
For 2'-F-ANA-dG(ibu) Phosphoramidite, reported solubility: DMSO: Soluble: =10 mg/ml Ethanol: Sparingly Soluble: 1-10 mg/ml.
Names and search terms
Confirmed or normalized name variants
- 2'-ara-2'-F-2'-dG Phosphoramidite
- 2'-F-2'-ara-ibu-dG Phosphoramidite
- 2'-F-dG(iBu)-ANA-CE Phosphoramidite
- 2'-F-2'-ara-N2-ibu-dG phosphoramidite
- 9-[2-FLUORO-2-DEOXY-5-O-DMTr-B-D- ARABINOFURANOSYL]-N2-ISOBUTYRYL- GUANINE-3-O-CE-AMIDITE
- 5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-arabinofuranosyl-deoxyguanosine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 1404463-20-2
- Protected oligonucleotide phosphoramidite building block
- 2'-fluoro modification
- phosphoramidite coupling group
- 2'-F-ANA Phosphoramidites
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-F-ANA-dG(ibu) Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-ANA-dG(ibu) Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FAP-00052'-F-ANA-dC(Bz) Phosphoramidite
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2'-F-ANA Phosphoramidites · CAS: N/A
BX-2FAP-00105'-Dimethoxytrityl-N2-isobutyryl-2'-deoxy-2'-fluoroarabinoguanosine 3'-[(2-cyanoethyl)-(N, N-diisopropyl)]-phosphoramidite
2'-F-ANA Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for 2'-F-ANA-dG(ibu) Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAP-0003 and CAS 1404463-20-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-F-ANA-dG(ibu) Phosphoramidite or the named structural feature represented by this product.