LNA Locked Nucleosides
2'-O-4'-C-Locked-rA
Quick view. We supply 2'-O-4'-C-Locked-rA as an LNA adenosine nucleoside intermediate for preparing amidites, supports and analogs. CAS 206055-70-1. Catalog target purity: ≥98%.
Product profile
2'-O-4'-C-Locked-rA is classified as nucleoside or protected nucleoside intermediate (Formula C11H13N5O4; molecular weight 279.25).
2'-O-4'-C-Locked-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-4'-C-Locked-rA, storage: Store at -20°C. Form: Solid.
Names and search terms
Confirmed or normalized name variants
- LNA-A
- LNA Adenosine
- 4'-C-Methyleneadenosine
- 2'-O,4'-C-Methyleneadenosine
- 2’-O,4’-C-Methyleneadenosine, LNA-A
- 9H-Purin-6-amine, 9-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-
- 9-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-9H-purin-6-amine
Useful catalog search terms
- CAS 206055-70-1
- Nucleoside or protected nucleoside intermediate
- conformationally locked sugar
- LNA Locked Nucleosides
Physicochemical data
| Key chemistry motifs | conformationally locked sugar |
|---|---|
| Boiling point | 660.0±65.0 °C(Predicted) |
| Density | 2.14±0.1 g/cm3(Predicted) |
| pKa | 12.98±0.60(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | [C@@]12([H])[C@]([H])(O)[C@@](CO)(O[C@H]1N1C3=C(N=C1)C(N)=NC=N3)CO2 |&1:0,2,5,9,r| |
| InChI | InChI=1/C11H13N5O4/c12-8-5-9(14-3-13-8)16(4-15-5)10-6-7(18)11(1-17,20-10)2-19-6/h3-4,6-7,10,17-18H,1-2H2,(H2,12,13,14)/t6-,7+,10-,11+/s |
| InChIKey | GHKDRNDFVCEETA-MIRGOXCMNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe 2'-O-4'-C-Locked-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
Frequently asked questions
Can the package size for 2'-O-4'-C-Locked-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0004 and CAS 206055-70-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-O-4'-C-Locked-rA or the named structural feature represented by this product.