Reverse Phosphoramidites
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite
Quick view. We supply 3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite as a reverse-orientation 2'-fluoro adenosine amidite for polarity-inverted oligonucleotide synthesis. CAS 2227293-35-6. Catalog target purity: ≥98%.
Product profile
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C47H51FN7O7P; molecular weight 875.92).
3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
For 3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMT-2'-F-dA(Bz)-5'-CE-Phosphoramidite
- 3'-O-DMTr-2'-F-dA(Bz)-5'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 2227293-35-6
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- 2'-fluoro modification
- phosphoramidite coupling group
- Reverse Phosphoramidites
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification; phosphoramidite coupling group |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-RP-00053'-O-DMTr-2'-O-MOE-rT-5'-CE-Phosphoramidite
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BX-RP-00063'-O-DMTr-2'-O-Me-rU-5'-CE-Phosphoramidite
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BX-RP-00073'-O-DMTr-2'-dG(dmf)-5'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for 3'-O-DMTr-2'-F-dA(Bz)-5'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-RP-0001 and CAS 2227293-35-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Reverse Phosphoramidites product family and its named chemistry.