Nucleoside Protection & Derivatization Reagents

4,4'-Dimethoxytriphenylmethyl chloride (DMT-Cl)

Quick view. An electrophilic tritylating reagent used to install the acid-labile 4,4'-dimethoxytrityl (DMTr) protecting group. CAS 40615-36-9. Catalog target purity: Specification on request.

Structure and identity

The structure drawing for this item is being finalized. Use the CAS number and machine-readable identifiers below to confirm the requested protecting groups, stereochemistry, salt or counterion and hydration state before ordering.

Identifiers available

CAS, molecular formula, SMILES or InChI data are shown below when available.

Identity control

We withhold a drawing when a related compound, alternate salt or incompletely specified stereoisomer could be mistaken for the requested material.

Qualification output

Agreed identity and purity criteria are documented in the quotation, specification and lot-specific data package.

Catalog numberBX-PDR-0002

CAS number40615-36-9

PuritySpecification on request

Pack sizeCustomized to customer requirements

Product profile

Material identity

4,4'-Dimethoxytriphenylmethyl chloride (DMT-Cl) is classified as trityl-type nucleoside protection and derivatization reagent (Formula C21H19ClO2; molecular weight 338.8).

Typical application

4,4'-Dimethoxytriphenylmethyl chloride (DMT-Cl) — Selective protection of the 5'-hydroxyl group in nucleoside synthesis.

Handling focus

For 4,4'-Dimethoxytriphenylmethyl chloride (DMT-Cl), confirm the current specification, storage conditions and downstream-method compatibility before routine use.

Names and search terms

Confirmed or normalized name variants

1,1'-(Chlorophenylmethylene)bis(4-methoxybenzene)
4,4'-Dimethoxytriphenylmethyl chloride
DMT-Cl

Useful catalog search terms

CAS 40615-36-9
Trityl-type nucleoside protection and derivatization reagent
Nucleoside Protection & Derivatization Reagents

Physicochemical data

SMILES	COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)Cl
InChI	InChI=1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3
InChIKey	JBWYRBLDOOOJEU-UHFFFAOYSA-N

Release documentation

Lot-specific CoA

The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.

Analytical package

Additional HPLC, MS or NMR documentation can be agreed during technical review where available.

Additional application examples

Installation of a DMTr handle before phosphoramidite preparation and solid-phase oligonucleotide assembly.

Frequently asked questions

Can the package size for 4,4'-Dimethoxytriphenylmethyl chloride (DMT-Cl) be customized?

Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.

What information should be included in a quote request?

Quote catalog number BX-PDR-0002 and CAS 40615-36-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.

Product-family literature

The publications below provide peer-reviewed context for the Nucleoside Protection & Derivatization Reagents product family and its named chemistry.

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